| 產(chǎn)品編號 | bs-13144R-Gold |
| 英文名稱 | Rabbit Anti-FARP1/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的軟骨細(xì)胞Ezrin樣蛋白抗體 |
| 別 名 | CDEP; Chondrocyte derived ezrin like protein; FERM RhoGEF and pleckstrin domain containing protein 1; FERM RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived). PLEKHC2; FARP1_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞類型標(biāo)志物 細(xì)胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 119kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FARP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: FARP1 (FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1), also known as PLEKHC2 or CDEP, is a 1,045 amino acid protein that contains one FERM domain, one DH domain and two PH domains. Existing as multiple alternatively spliced isoforms that are expressed in fetal heart, brain and spleen, as well as in adult lung, kidney and testis, FARP1 is thought to function as a Rho-guanine nucleotide exchange factor that may play a role in linking the cell membrane to the cytoskeleton. The gene encoding FARP1 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. Function: The FARP1 protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain, and is believed to be a member of the band 4.1 superfamily, whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for the FARP1 gene, which shows increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. Subcellular Location: Cytoplasmic. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FERM domain. Contains 2 PH domains. Database links: UniProtKB/Swiss-Prot: Q9Y4F1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
