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Rabbit Anti-Tollip/PE-Cy7 Conjugated antibody (bs-18168R-PE-Cy7)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-18168R-PE-Cy7
英文名稱 Rabbit Anti-Tollip/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的Toll蛋白相互作用蛋白抗體
別    名 Adapter protein; FLJ33531; IL 1RAcPIP; IL1RAcPIP; TOLIP; TOLIP_HUMAN; Toll interacting protein; Toll-interacting protein; tollip.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Xenopus laevis)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tollip
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

Function:
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.

Similarity:
Belongs to the tollip family.
Contains 1 C2 domain.
Contains 1 CUE domain.

Database links:

Entrez Gene: 54472 Human

Entrez Gene: 423099 Chicken

Entrez Gene: 539480 Cow

Entrez Gene: 54473 Mouse

Entrez Gene: 361677 Rat

Entrez Gene: 336876 Zebrafish

Omim: 606277 Human

SwissProt: Q5ZK05 Chicken

SwissProt: Q2LGB5 Cow

SwissProt: Q9H0E2 Human

SwissProt: Q9QZ06 Mouse

SwissProt: A2RUW1 Rat

SwissProt: Q7ZV43 Zebrafish

Unigene: 368527 Human

Unigene: 103551 Mouse

Unigene: 137040 Rat

Unigene: 79855 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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