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Rabbit Anti-Plakophilin 3/BF555 Conjugated antibody (bs-12703R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-12703R-BF555
英文名稱 Rabbit Anti-Plakophilin 3/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的橋粒斑菲素蛋白3抗體
別    名 PKP 3 ; PKP3 ; PKP3_HUMAN ; Plakophilin 3b ; Plakophilin-3 ; Plakophilin3.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Plakophilin 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Function:
May play a role in junctional plaques.

Subcellular Location:
Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.

Tissue Specificity:
Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues.

Similarity:
Belongs to the beta-catenin family.
Contains 8 ARM repeats.

Database links:

Entrez Gene: 11187 Human

Entrez Gene: 56460 Mouse

Entrez Gene: 293619 Rat

Omim: 605561 Human

SwissProt: Q9Y446 Human

SwissProt: Q9QY23 Mouse

Unigene: 534395 Human

Unigene: 350037 Mouse

Unigene: 144803 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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