產(chǎn)品編號(hào) | bs-23128R-BF488 |
英文名稱(chēng) | Rabbit Anti-CD163/BF488 Conjugated antibody |
中文名稱(chēng) | BF488標(biāo)記的CD163抗體 |
別 名 | Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
研究領(lǐng)域 | 心血管 免疫學(xué) 細(xì)胞膜受體 |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Human, (predicted: Mouse, Rat, ) |
產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 121kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human CD163 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant. Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. Subcellular Location: Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. Tissue Specificity: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. Post-translational modifications: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated. Similarity: Contains 9 SRCR domains. Database links: Entrez Gene: 9332 Human Entrez Gene: 93671 Mouse Omim: 605545 Human SwissProt: Q86VB7 Human SwissProt: Q2VLH6 Mouse Unigene: 504641 Human Unigene: 37426 Mouse Unigene: 203204 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD163是SRCR超家族成員之一,又稱(chēng)為血紅蛋白清道夫受體(hemoglobin scavenger receptor, HbSR)、M130或p155。CD163的表達(dá)水平受很多因素調(diào)節(jié),糖皮質(zhì)激素及抗炎介質(zhì)如IL-10以及IL-6能上調(diào)CD163, 而促炎介質(zhì)如脂多糖(lipopolysaccharide, LPS)、γ-干擾素(interferon-γ, IFN-γ)以及TNF-α則抑制CD163表達(dá)。 CD163是一種I型膜蛋白,又稱(chēng)為M130抗原、Ber-Mac3、Ki-M8或SM4。CD163限制性表達(dá)于單核/巨噬細(xì)胞系,所有循環(huán)系統(tǒng)的單核細(xì)胞和大多數(shù)組織(除外淋巴濾泡套區(qū)和生發(fā)中心)的巨噬細(xì)胞均陽(yáng)性表達(dá),主要用于單核/巨噬細(xì)胞的檢測(cè)。 |
| 91超碰在线播放 | 熟女酒井千波一区二区三区 | 国产性猛交 XX 乱 | 国产肥白大熟妇BBBB | 国产真实亲子伦脏话对白免费影视 | 国产69精品久久久久久 | 国产乱人妻偷人伦子伦 | 国产一级a毛一级a看免费视频野外 | 日韩人妻无码一区二区 | 国产成人无码高清在线视频 | 欧美一区二区鲁丝袜片 | 四川顶级毛片A片国产 | 久久久国产精品一区二区白洁老师 | 久久澡狠l澡欧美老妇 | 人妻少妇精品无码专区 | 国产精品一级毛片无码四季 | 性猛交AAAA片免费看直播软件 | 2021人人操人人爱 | 无码人妻丰满熟妇一区二区三区 | 亚洲AV无码乱码在线观看性色 | 国内精品人妻色欲无码久久久 | 在线免费观看黄片 | 国产精品高潮呻吟AV无码 | 少妇一级婬片50分钟 | 91国内精品久久久久夏晴子 | 久久99久久99精品蜜柚传媒 | 亚洲无码视频在线观看 | 日韩内射美女人妻一区二区三区 | 无码人妻丰满熟妇区八十路久久 | 成人av在线观看网站 | 污黄视频在线免费观看 | 香蕉网在线免费播放视频 | 无码人妻一区二区三区免责 | 国精产品一区二区三区在线观看 | 久久久久久一级毛片免费 | 久久久久成人精品无码 | 国产人成视频在线观看 | 少妇把腿扒高潮爽让我添 | 近親相姦五十路の在线 | 欧洲久久久hhhhh |